2-4-D Amine Mixing Ratio Per Gallon Guide To Kill Weeds

Are you wondering about how to get the perfect 2-4-D amine mixing ratio to kill weeds? We will give you the answer in this guide!

2-4-D, or 2,4-D, is a popular component in most pesticides used for vegetation control. This herbicide is suitable for efficiently killing hundreds of weed species without significantly injuring your lawn. Being an auxin-type herbicide, 2-4-D specifically alters the growth of cells in the plant, leading to its death.

However, it is essential to get the correct mixing ratio, timing, and application rate for effective weed management. If applied heavily, an incorrect calculation would result in poor weed control or even damage to your grass.

So, what should be the mixing ratio of 2-4-D? Make your way through this article to learn everything from mixing ratio to application tips and tricks for the effective elimination of non-grassy weeds.


  • Easy to mix and use
  • Simple yet effective formula
  • Clear instructions on the label
  • Comes from a reliable brand
  • Suitable for applying to large areas
  • Effectively control unwanted weed
  • Easy to mix and apply for weed control
  • Comes with complete instructions
  • A relatively affordable choice

The 3 Best 2-4-D Amine Mixing Ratio Weed Killers Review

Here is a detailed review of some of the high-end 2-4-D amine weed killers to help you reach the decision quickly.

1. Southern Ag Amine 2,4-D Weed Killer – Top Pick

[lasso ref=”southern-ag-amine-24-d-weed-killer-32oz-quart” id=”4691″ link_id=”5034″]

Just make sure to dilute it enough with the water to prevent any damage to the plants.

The overall concentration is 46.3%. Add two to three tablespoons of this weed killer into three to five gallons to get the right dilution ratio. Depending on the concentration, it takes from one to four pints per acre to eliminate the weed, making it an economical pick.

Item Weight: 2 pounds

Item dimensions: 3 x 1.5 x 5 inches

Liquid Volume: 948 mL

Item Form: Liquid

It is suitable for killing broadleaf weeds and woody plants. You can use it in lawns, parks, golf courses, fences, pastures, small grains to keep the area weed-free. The effect can be seen in only two weeks after the application. It is also recommended to add a little soap in the solution for an even spread.


  • Great packaging and pocket-friendly
  • Comes from a reliable brand
  • Suitable for applying to large areas
  • Effectively control unwanted weed

2. Drexel De-Amine 4 Weed Killer – Best Premium Weed Killer

[lasso ref=”drexel-de-amine-4-also-known-as-2-4-d-amine-weed-killer-128oz-gallon” id=”4692″ link_id=”5035″]

Adding two to three tablespoons of this concentrated solution to three to five gallons of water would easily cover 1000 square feet of area.

Item Weight: 10.01 pounds

Item dimensions: 10.43 x 8.98 x 5.04 inches

Liquid Volume: 3.8 lbs.

Item Form: Liquid

Apart from lawns, this weed killer can be applied on a range of areas, including pastures, parks, fences, golf courses, small grains, as well as non-crop sites. You can observe dying weeds after only weeks of application. The low volatile amine form in the gallon effectively kills broadleaf weeds and woody plants.


  • Easy to mix and use
  • Simple yet effective formula
  • Clear instructions on the label
  • Comes in a hard bottle for secure use
  • Can be applied to a range of areas

3. Compare-N-Save 2-4-D Amine Weed Killer – Best Budget-Friendly

[lasso ref=”compare-n-save-2-4-d-amine-broadleaf-killer” id=”2467″ link_id=”5036″]

Compare-N Save is way cheaper than its rivals. It comes in a 1-quart plastic bottle to ensure safe storage. The overall concentration is 46.8%, slightly higher than other products on the list.

However, the mixing ratio is quite similar. Just add three tablespoons of weed killer into one gallon of water, and this solution would be enough to process a 43,280 sq. ft. area.

Item Weight: 2.25 pounds

Item dimensions: 3.5 x 3.5 x 9 inches

Liquid Volume: 32 fluid ounces

Item Form: Liquid

This weed killer mainly stands out for eliminating almost 150 listed weeds, which is pretty impressive. You will get a weed-free area only after two weeks of application.

With all the instructions written on the bottle, it is a reasonable choice for amateurs. You can use it for corn, soybeans, pastures, rangelands, and other listed crops. When it comes to non-crop sites, this weed killer is great for lawns, parks, golf courses, roadsides, fence rows, as well as athletic fields.


  • High concentration than other products
  • Easy to mix and apply for weed control
  • Comes with complete instructions
  • A relatively affordable choice
  • Suitable for both crop and non-crop sites

How Much 2,4-D Per Gallon of Water

2,4-D alters the growth pattern of the plants, thereby causing their death. It kills broadleaf weeds by allowing an uncontrolled division and growth of cells that transport water and other nutrients. This formula is available in different forms, including acids, esters, and salts.

Before application, you must understand the proper usage and application of this herbicide. This will increase the effect and prevent any unwanted damage to your grass. For safe and effective use, you must observe the proper 2,4-D mixing ratio.

Even a slight variation could be damaging and require you to spray for effective weed management repeatedly.

2-4-d amine mixing ratio

2,4-D Mixing Ratio

For most 2,4-D products, the ideal mixing ratio is five tbsp (2.5 ounces) of the concentrate per gallon of the water. It is enough for killing weed over 400 sq. ft. of the yard. However, if you have a bigger yard of 1000 sq. ft., add 6.5 oz of the 2,4-D amine to 2.5 gallons of water.

It is essential to carefully read manufacturers’ instructions as these products come in varying concentrations. The herbicide’s effectiveness and mixing ratio also depend on the method and equipment you will be using for application.

Mix 2,4-D For A Hand Sprayer Or Backpack

The generic mixing ratio will do fine if you are using a backpack sprayer or tank. Add five tbsp (2.5 ounces) of the liquid concentrate per gallon of water to cover the 400 sq. ft. area. This solution would be strong enough to eliminate weed but not enough to cause any damage to the grass in the yard.

While mixing and applying the herbicide, follow these simple steps.

  • Make sure to wear gloves and goggles while preparing the solution.
  • Pour the concentrate first and then add water. This will allow proper mixing of the ingredients.
  • Add the proper amount of water to prepare the right 2,4-D dilution.
  • It is not necessary to drench the plants and grass with this herbicide. Just apply it evenly over the grass for proper coverage.

Mix Ratio For 2,4-D Hose End Sprayer

When using a hose-end spray to apply the herbicide, add 2.5 oz of the contrite per gallon to the water. A typical garden hose has enough capacity to contain up to 6 and ½ ounces of this herbicide. It is enough to cover a 1000 sq. ft. yard area for weed elimination.

There is no need to fill the reservoir with water. Simply set the hose-end sprayer to mix the recommended amount of concentrate with water flowing through the hose. The manufacturer’s recommended mixing ratio is sufficient for processing up to 2500 sq. ft. area.

If you have a square or rectangular lawn, simply multiply its length by the width to calculate the total area.

2,4-D Mixing Ratio For Spray Bottle

A spray bottle is a great choice to spot treat the unwanted weed growing in your lawn. You are suggested to use a herbicide spray bottle as it is chemical-resistant. Mix 2 and ½ tbsp of the concentrate in the spray bottle (32 ounces), and this would be enough to cover a 250 sq. ft. area. Using a spray bottle allows you to tackle and kill a lot of weed quickly and easily.

You can also add a compatible surfactant to the solution for better coverage. Make sure not to employ the same bottle for insecticide and fungicide treatment.

How Many Acres Per Gallon Of Diluted 2,4-D?

2,4-D concentrate generally needs to be diluted. A dilution of one gallon of herbicide in 15-gallon water is usually enough to treat one acre of site. Two annual applications with 1.8 gallons on one acre are enough for effective weed management.

The spray volume is five to twenty gallons of water with ground equipment, while it’s one to five gallons per acre by an aircraft. You can use a higher amount to ensure maximum coverage and killing of the weed.

It is recommended to use a lower dose of the herbicide for susceptible weeds. However, you must opt for repeated applications with higher dosages to eliminate weed species having a rapid growth rate.

Make sure to carefully read the instructions before diluting the herbicide. Don’t add oil, surfactant, or adjuvants in the mixture unless mentioned in the instructions, as it can affect the potency of the herbicide.

Is 2,4-D Harmful If Mixed Incorrectly?

2,4-D is a powerful herbicide, so the timing and rate of spray are highly crucial for effective weed management. A slight variation in mixing ratio or incorrect application could lead to inefficient weed control or, even worse, crop injury.

A previously injury-resistant crop can be damaged when treated with a mixture containing a high concentration of herbicide. An over-application can harm the grass. Some significant signs of damaged grass include:

  • Brown or dead grass
  • Dry grass that lacks water
  • Pale yellow or bleached-looking grass

To avoid damaging the grass, make sure to mix an adequate amount of concentrate in the right amount of water. Applying a more potent mixture would increase the effect but overload and harm your grass.

Different forms of 2,4-D

2,4-D herbicide is available in different forms on the market. The commonly used among them are discussed in detail below.

  • Acids

The first form is 2,4-D acid that is generally dry. It does not dissolve in water, and thus a liquid carrier is required for proper mixing. When the water is added to dilute the herbicide, the liquid carrier allows the acid to stay in the solution. The mixture preparation can vary depending on the ratio of herbicide, the type of carrier used, and the derivative.

  • Salts

The salt form of 2,4-D is generally available as ammonium or sodium salts. These are powder-like and can be easily dissolved in the water for easy application. You need to add the wetting agent while preparing the mixture to allow an even coverage of the area.

  • Esters

Compared to salts, the esters form of the 2,4-D dissolves in water at a relatively slower rate. That’s why manufacturers sell ester forms with oil. They readily mix with the water and form emulsion to allow easy application.

How to Apply 2,4-D Spray

The application of 2,4-D requires proper care and attention to prevent any damage. Here is a step-by-step guide to help you understand the whole process.

  • First of all, prepare all the accessories you’ll be needing. Make sure to wear gloves while handling and mixing the herbicide. Being a human carcinogen, 2,4-D could lead to different types of blood cancers such as lymphoma and sarcoma.
  • Get a surfactant and a high-pressure hand-sprayer for easier application.
  • It is suggested not to spray the 2,4-D when the wind speed is high because it can blow the product to unwanted places. Always apply the mixture when the wind speed is below six to seven mph.
  • Attach a nozzle tip to the spray tank. Adjust 20 psi pressure and turn on the agitator. Make sure to keep it on during the whole process.
  • Add an adequate amount of herbicide and slowly fill the tank with enough water. You can also add a surfactant in the mixture to allow good coverage for the targeted killing of weed.
  • Make sure to keep the agitator running for even mixing of the ingredients. Apply the mixture to spot treatment of the weeds by spraying the herbicide on stems and leafy parts.
  • Once the application is completed, allow the herbicide to get dried. Make sure to keep your uncovered skin from getting in contact with the fumes from the spray. Plus, keep the animals and children from the application area as well.
  • Wash the tank and gloves separately.

2,4-D Ratio Tips and Tricks

Now that you fully understand the entire process of the 2,4-D application let’s look at valuable tips and tricks to help you all the way along.

  • 2,4-D works slowly, so you will start noticing the result in almost two weeks. It usually takes more than two weeks for the weed to die.
  • Less sensitive and fast-growing weeds require more than two applications.
  • Using this herbicide would sterilize the soil, and the effect depends on multiple factors such as rainfall, the concentration of chemicals, irrigation, soil, and temperature.
  • While it is suggested not to use the same equipment and a spray bottle for other chemicals, clean them thoroughly before using them for other materials.
  • Ornamental plants and susceptible crops can be damaged even when treated with a small amount of herbicide. Make sure the spray never reaches them to prevent any injury.
  • The 2,4-D acid is non-corrosive and harmless for both animals and humans.

Does 2-4-D Require A Surfactant?

There is always a question of whether you should use a surfactant with an herbicide or not. Surfactants are added to the herbicide mixture so they can stick to the plant leaves. This wetting agent improves the effect of the effectiveness of the herbicide by increasing the coverage and penetration.

You can use a non-ionic surfactant with the 2,4-D amine to allow uniform coverage. It works by minimizing the water’s surface tension, thereby allowing the herbicide to spread evenly on the surface. Adding a surfactant to the mixture proves helpful in controlling broadleaf weeds, including common vetch and wild oats. Add one teaspoon of surfactant to a gallon of water. This will cause the herbicide to stick and kill weed effectively.

There are commercial surfactants available that feature multiple specifications for mixing rates. Dish soap can be an effective alternative for commercial surfactants.

When To Apply 2-4-D Amine

Effective weed management and control require you to consider a few factors prior to application.

  • Moisture Level

A higher moisture level in the field could cause the herbicide to fail. The reason for this is the quick breakdown of esters and salts of the herbicide due to wet conditions. Consequently, the effectiveness of herbicides decreases, and you have to wait longer for full effect. You need to consider the moisture content of the site before spraying the herbicide to maximize its use.

  • Temperature Level

Temperature is crucial in the overall effectiveness of the herbicide. It works more effectively when the temperature is warm and humid. However, temperature inversion could result in a drift that may impact other areas that you don’t want.

  • Wind Speed

The essential factor to consider is the wind speed, as applying the herbicide during inadequate wind speed can cause adverse effects on the crop. The recommended speed for the ideal application of herbicide is from three to seven m/s.

While a higher wind speed would lead to off-target drift and missing out entirely on the intended purpose, the wind speed below three m/s causes improper application.

  • Season

The season you choose for herbicide application is also vital for effectiveness. Applying the herbicide in the fall is recommended as it is more effective than the spring applications. The reason is the active movement of water and nutrients from foliage to roots of weeds during the fall to prepare for the upcoming winter. Applying the herbicide during fall would help in maximum absorption of the herbicide by foliage and its transport to roots, resulting in the quick death of the weed.

How Long For 2-4-D Amine To Work?

Generally, it takes from one to two weeks to observe the effect of 2,4-D amine. Some signs like discoloration and wilting of leaves can be seen even after two days of application. However, you may have to wait for up to a month to ensure complete eradication of the weed.

How To Increase The Effectiveness Of 2-4-D Amine Mixing Ratio

Follow these simple steps to prevent the quick breakdown of 2,4-D amine in areas with higher moisture content.

  • It is better to apply 2,4-D amine on young weeds.
  • Apply the herbicide when the wind speed is adequate to avoid crop injury and drift.
  • The ideal temperature for herbicide application of below 90° F.
  • Don’t apply herbicide during heavy rain as it would decrease absorption.

How Long Does 2-4-D Need To Be On Before Rain?

To ensure the maximum absorption of 2,4-D, it is better to allow the herbicide to rest for at least one day. The amine formulation of 2,4-D gets absorbed within six to eight hours, while the ester formulation needs merely an hour of the rain-free period.

What Weeds Does 2-4-D Amine Kill?

The adequate 2,4-D mixing ratio can kill most types of weeds effectively. You can use this herbicide for a range of weeds; however, the action rate is relatively slower than other chemicals available out there.

Here are the common observations in different types of weeds when treated with 2,4-D herbicide.

  • Russian knapweed

2,4-D amine effectively kills almost 95% to 100% of this Russian knapweed when applied in the early rosette stage. However, you may need to use a wetting agent such as surfactant as this weed is difficult to wet.

  • Klamath weed

The effect of 2,4-D amine on Klamath weed is different from Russian knapweed. The herbicide works more effectively on Klamath weed when it is fully developed. You need to spray before the weed starts blooming to kill it.

  • Cattails

Cattails are deep-rooted; however, you can kill them with the adequate spray of 2,4-D amine. Since they become resilient in summer, adding 3 gallons of diesel oil to 100 gallons of spray is recommended. This will improve the penetration of herbicide and kill the weed quickly.

  • Dandelion

Applying this herbicide once would be enough to kill the dandelion weed completely.

  • Water weeds

Water weeds include hydrocotyle, water hyacinth, and yellow waterweed. A single spray of herbicide on the above-water parts of these weeds would kill them.

  • Nutgrass

Nutgrass is less sensitive to the 2,4-D amine. However, repeated applications may help in its killing.

2,4-D also kills:

  • Canada thistle
  • Goldenrod
  • Alder
  • Coffeweed
  • Nettle
  • Pennycress
  • Jewelweed
  • Pepperweed
  • Ragweed
  • Red Clover
  • Purslane
  • Sweet Clover
  • Velvetleaf
  • Sagebrush
  • Toadflax
  • Wild carrot
  • Virginia Creeper
  • Wild parsnip
  • Tumbleweed

What Type Of Grass Can You Use 2-4-D On?

Cereals and a variety of grasses (foxtail, horsetail, watergrass, poison oak, etc.) tend to be resistant to the use of 2,4-D. This particular chemical has been used for spot treatment and barley, wheat, and other grain fields.

    • Barley and Wheat – To use in barley and wheat fields, you should stick to the 8-12 oz of chemical per acre (mixed with 100-200 gallons of water). Keep in mind that young crops could get damaged. However, grains that are at least 4-6 inches high will remain safe.
    • Rice – 2,4-D is also used to kill weeds harming rice fields. The water weeds include burhead and arrowhead lily. 16 oz of chemical should do the trick.
    • Corn and milo – Infestation of perennial weeds (wild morning glory and kelp) can be reduced by a single treatment application the rows are covered by crops. 16-24 oz is recommended.
  • Turfs and grass pastures – Use 16-24 oz for such areas. If the grass is still young, stick to 12 oz.
  • Lawns – You should use 24 oz for treating lawns to kill dandelion, pennywort, speedwell, and more. Red oxalis, crabgrass, and bermudagrass won’t be affected.

Lawns To Avoid Using 2-4-D

Use the 2,4-D herbicide for getting rid of weeds in grass pastures, lawns, and grain fields. Many crop plants will be damaged due to this chemical. Ensure the chemical, when spraying, doesn’t touch ornamental plants or nearby crops.

Finally Thoughts on 2-4-D Amine Mixing Ratio

This brings us to the end of this extensive 2-4-D amine mixing guide. Now you know everything about 2-4-D amine to help you tackle the unwanted weeds in your lawn or crop fields. You can choose any of our recommended products to remove the weed effectively. However, remember all tips and tricks during mixing and application. Plus, always consider necessary factors while applying the 2-4-D amine so you don’t damage your lovely plants.


Does 2-4-D Amine need a surfactant?

Yes, adding a surfactant to the 2,4-D amine mixture is essential. It will improve the effectiveness of herbicide by allowing it to stick to the plant leaves. A single teaspoon of surfactant per gallon of water is enough to improve the coverage and effect of weed killer.

What is the ratio of 2-4-D to water?

The ideal mixing ratio is 2.5 oz of liquid concentrate per gallon of water. This mixture is enough to treat up to 400 sq. ft. of yard area. You can increase the ratio depending on the area that needs to be covered.

When should I put 2-4-D on my lawn?

The best time for 2-4-D amine mixing ratio application on the lawn is when weeds are young and actively growing. Ensure to spray on windless days and when the temperature is warm, preferably below 90° F.

How long does it take for 2-4-D to work?

While the discoloration of plants can be seen after only two days of 2,4-D amine, it can take up to at least two weeks for the herbicide to work completely. You have to wait from two weeks to a month to ensure the complete elimination of weed.

How often can I spray 2-4-D?

It is recommended not to spray 2-4-D amine mixing ratio more than once per month. Applying herbicide more than once in the 30-day period could lead to an overload and harm the grass.

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